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β klotho  (R&D Systems)


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    R&D Systems β klotho
    β Klotho, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 25 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/%CE%B2+klotho+antibody/pmc13098676-151-46-47?v=R%26D+Systems
    Average 93 stars, based on 25 article reviews
    β klotho - by Bioz Stars, 2026-07
    93/100 stars

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    Image Search Results


    Validation of AB4 for IHC using human spleen (KLB-negative) and liver tissue (KLB-positive). KLB protein expression in (A) human spleen tissue with (B) negative control and (C) human liver tissue with (D) negative control. Scale bars represent 200 μm.

    Journal: Gastro Hep Advances

    Article Title: Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH

    doi: 10.1016/j.gastha.2025.100745

    Figure Lengend Snippet: Validation of AB4 for IHC using human spleen (KLB-negative) and liver tissue (KLB-positive). KLB protein expression in (A) human spleen tissue with (B) negative control and (C) human liver tissue with (D) negative control. Scale bars represent 200 μm.

    Article Snippet: Primary and secondary antibodies AB1 (106794, Abcam), AB2 (SAB2108630, Sigma Aldrich), AB3 (MAB5889, R&D systems), and AB4 (AF5889, R&D systems) for KLB were used for antibody validation.

    Techniques: Biomarker Discovery, Expressing, Negative Control

    KLB protein expression levels using AB4 and CK19 in human and monkey tissues. KLB protein expression levels in (A) human liver (200 μm) with (B) negative control (200 μm), (C) human bile ducts in liver (80 μm) with (D) CK19 staining as positive control (80 μm), (E) monkey liver (90 μm) with (F) negative control (90 μm), (G) human gallbladder (200 μm) with (H) negative control (200 μm) and (I) CK19 staining as positive control (300 μm).

    Journal: Gastro Hep Advances

    Article Title: Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH

    doi: 10.1016/j.gastha.2025.100745

    Figure Lengend Snippet: KLB protein expression levels using AB4 and CK19 in human and monkey tissues. KLB protein expression levels in (A) human liver (200 μm) with (B) negative control (200 μm), (C) human bile ducts in liver (80 μm) with (D) CK19 staining as positive control (80 μm), (E) monkey liver (90 μm) with (F) negative control (90 μm), (G) human gallbladder (200 μm) with (H) negative control (200 μm) and (I) CK19 staining as positive control (300 μm).

    Article Snippet: Primary and secondary antibodies AB1 (106794, Abcam), AB2 (SAB2108630, Sigma Aldrich), AB3 (MAB5889, R&D systems), and AB4 (AF5889, R&D systems) for KLB were used for antibody validation.

    Techniques: Expressing, Negative Control, Staining, Positive Control

    KLB protein expression levels using AB4 along the human gastrointestinal tract. KLB protein expression levels in (A) human stomach (200 μm) with (B) negative control (200 μm), and (C) human colon tissue (90 μm) with (D) negative control (90 μm).

    Journal: Gastro Hep Advances

    Article Title: Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH

    doi: 10.1016/j.gastha.2025.100745

    Figure Lengend Snippet: KLB protein expression levels using AB4 along the human gastrointestinal tract. KLB protein expression levels in (A) human stomach (200 μm) with (B) negative control (200 μm), and (C) human colon tissue (90 μm) with (D) negative control (90 μm).

    Article Snippet: Primary and secondary antibodies AB1 (106794, Abcam), AB2 (SAB2108630, Sigma Aldrich), AB3 (MAB5889, R&D systems), and AB4 (AF5889, R&D systems) for KLB were used for antibody validation.

    Techniques: Expressing, Negative Control

    KLB protein expression levels using AB4 in human adipose tissue and pancreas. KLB protein expression levels in (A) human adipose tissue with (B) negative control, and (C) human pancreas with (D) negative control and (E) insulin staining as positive control to visualize the islets of Langerhans. Scale bars represent 200 μm.

    Journal: Gastro Hep Advances

    Article Title: Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH

    doi: 10.1016/j.gastha.2025.100745

    Figure Lengend Snippet: KLB protein expression levels using AB4 in human adipose tissue and pancreas. KLB protein expression levels in (A) human adipose tissue with (B) negative control, and (C) human pancreas with (D) negative control and (E) insulin staining as positive control to visualize the islets of Langerhans. Scale bars represent 200 μm.

    Article Snippet: Primary and secondary antibodies AB1 (106794, Abcam), AB2 (SAB2108630, Sigma Aldrich), AB3 (MAB5889, R&D systems), and AB4 (AF5889, R&D systems) for KLB were used for antibody validation.

    Techniques: Expressing, Negative Control, Staining, Positive Control

    Quantified KLB protein levels using AB4 in liver biopsies of patients with varying stages of MASLD (n = 28). (A) Overview of patient liver biopsies with MASLD stained with AB4, separated into different fibrosis grades. (B and C) Association of KLB protein expression levels with typical MASLD characteristics, specifically (B) lobular inflammation (Kruskal–Wallis, P = .0168), (C) portal inflammation (Kruskal–Wallis, P = .0809), (D) fibrosis grade (Kruskal–Wallis, P = .6602), (E) steatosis grade (Kruskal–Wallis, P = .7834), and (F) ballooning (Kruskal–Wallis, P = .1097).

    Journal: Gastro Hep Advances

    Article Title: Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH

    doi: 10.1016/j.gastha.2025.100745

    Figure Lengend Snippet: Quantified KLB protein levels using AB4 in liver biopsies of patients with varying stages of MASLD (n = 28). (A) Overview of patient liver biopsies with MASLD stained with AB4, separated into different fibrosis grades. (B and C) Association of KLB protein expression levels with typical MASLD characteristics, specifically (B) lobular inflammation (Kruskal–Wallis, P = .0168), (C) portal inflammation (Kruskal–Wallis, P = .0809), (D) fibrosis grade (Kruskal–Wallis, P = .6602), (E) steatosis grade (Kruskal–Wallis, P = .7834), and (F) ballooning (Kruskal–Wallis, P = .1097).

    Article Snippet: Primary and secondary antibodies AB1 (106794, Abcam), AB2 (SAB2108630, Sigma Aldrich), AB3 (MAB5889, R&D systems), and AB4 (AF5889, R&D systems) for KLB were used for antibody validation.

    Techniques: Staining, Expressing

    KLB protein expression levels using AB4 and CK19 in human and monkey tissues. KLB protein expression levels in (A) human liver (200 μm) with (B) negative control (200 μm), (C) human bile ducts in liver (80 μm) with (D) CK19 staining as positive control (80 μm), (E) monkey liver (90 μm) with (F) negative control (90 μm), (G) human gallbladder (200 μm) with (H) negative control (200 μm) and (I) CK19 staining as positive control (300 μm).

    Journal: Gastro Hep Advances

    Article Title: Beta-Klotho Protein Expression in Healthy Human Tissues and Liver Biopsies From Patients With MASLD or MASH

    doi: 10.1016/j.gastha.2025.100745

    Figure Lengend Snippet: KLB protein expression levels using AB4 and CK19 in human and monkey tissues. KLB protein expression levels in (A) human liver (200 μm) with (B) negative control (200 μm), (C) human bile ducts in liver (80 μm) with (D) CK19 staining as positive control (80 μm), (E) monkey liver (90 μm) with (F) negative control (90 μm), (G) human gallbladder (200 μm) with (H) negative control (200 μm) and (I) CK19 staining as positive control (300 μm).

    Article Snippet: Next, sections were incubated overnight at 4 °C with 1:100 primary KLB (AF5889, R&D systems), 1:1000 CK19 (ab52625, Abcam), or 1:500 insulin antibody (A0564, Dako).

    Techniques: Expressing, Negative Control, Staining, Positive Control